Price range: $268.00 through $328.00
Background:This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | Blimp-1 |
| Reactivity | Human |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 92kD |
| MW(Observed) | 90-100kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:200; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1541R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | PRDM1 |
| Protein Name | PR domain zinc finger protein 1 |
| Other Name | PRDM1; / BLIMP1; / PR domain zinc finger protein 1; / BLIMP-1; / Beta-interferon gene positive regulatory domain I-binding factor; / PR domain-containing protein 1; / Positive regulatory domain I-binding factor 1; / PRDI-BF1; / PRDI-binding factor 1 |
| Species | Human |
| Gene ID | 639 |
| Uniprot | O75626, |
| Species.1 | Mouse |
| Gene ID.1 | 12142 |
| Uniprot.1 | Q60636 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Cytoplasm . |
| Tissue Expression | PCR rescued clones,Stomach, |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells.,similarity:Contains 1 SET domain.,similarity:Contains 4 C2H2-type zinc fingers.,subunit:Interacts with PRMT5., |
