SKU: WM1840 Categories: ,

U-Blot® CD127 Mouse mAb

Price range: $268.00 through $328.00

SKU: WM1840-50
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Product details

Background:
The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found. [provided by RefSeq, Dec 2015],

Specifications

TargetIL-7R
ReactivityHuman
ApplicationsFC,IF
MW(Calculated)52kD
MW(Observed)70kD
Host SpeciesMouse
IsotypeMouse IgG1/Kappa
Conjugate/ModificationUnmodified
Modification
Recommended Dilution RatioWB 1:4000-1:20000;IF 1:200-1:1000;FC:1 µg per million cells in 100 µl volume. For optimal results, the reagent should be titrated according to each specific application
FormulationPBS, pH 7.4
Source
PurificationProtein A
Purity
StorageStore at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Concentration
ClonalityMonoclonal
Clone NumberPTF0044
Immunogen
Sequence
SpecificityEndogenous
Gene NameIL7R
Protein NameInterleukin-7 receptor subunit alpha
Other NameIL7R;Interleukin-7 receptor subunit alpha;IL-7 receptor subunit alpha;IL-7R subunit alpha;IL-7R-alpha;IL-7RA;CDw127;CD antigen CD127
SpeciesHuman
Gene ID-13575
UniprotP16871
Species.1
Gene ID-2
Uniprot.1
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
BackgroundThe protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found. [provided by RefSeq, Dec 2015],
Cellular Localization[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; [Isoform 4]: Secreted.
Tissue Expression
Signaling_pathway
Research Areas
Function
RRID
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