Price range: $268.00 through $328.00
Background：
The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins , it forms a complex with BRCA1 and BRCA2 , thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq , Dec 2008] ,
| Size | 50μL/100μL |
| Target | CD168 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | 84kD |
| MW(Observed) | 84kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1984R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | HMMR IHABP RHAMM |
| Protein Name | Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein) (Receptor for hyaluronan-mediated motility) (CD antigen CD168) |
| Other Name | Hyaluronan mediated motility receptor; / Intracellular hyaluronic acid-binding protein; / Receptor for hyaluronan-mediated motility; / CD antigen CD168 |
| Species | Human |
| Gene ID | 3161 |
| Uniprot | O75330, |
| Species.1 | Mouse |
| Gene ID.1 | 15366 |
| Uniprot.1 | Q00547 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell surface . Cytoplasm . Cytoplasm, cytoskeleton, spindle . |
| Tissue Expression | Expressed in testis (PubMed:22965910). Expressed in the breast (PubMed:8890751). |
| Signaling_pathway | Environmental Information Processing >> Signaling molecules and interaction >> ECM-receptor interaction |
| Research Areas | >>ECM-receptor interaction |
| Function | Function:Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including the focal adhesion kinase occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity.,subunit:Subunit of the HARC complex.,tissue specificity:Expressed in breast cancer cell lines and in normal breast tissue., |
