U-Blot® CD180 Mouse mAb
Ucallm_WM1893-50
Price range: $268.00 through $328.00
Product details
Background:CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | CD180 |
| Reactivity | Human |
| Applications | FC, IF |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | Mouse IgG1,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IF 1:200-1:1000; FC:1 µg per million cells in 100 µl volume. For optimal results, the reagent should be titrated according to each specific application |
| Formulation | PBS, pH 7.4 |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Concentration | 0.5mg/ml |
| Clonality | Monoclonal |
| Clone Number | RMMF0105 |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | CD180 |
| Protein Name | CD180 antigen |
| Other Name | CD180; / LY64; / RP105; / CD180 antigen; / Lymphocyte antigen 64; / Radioprotective 105 kDa protein; / CD180 |
| Species | Human |
| Gene ID | 4064 |
| Uniprot | Q99467, |
| Species.1 | Mouse |
| Gene ID.1 | 17079 |
| Uniprot.1 | Q62192 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. |
| Tissue Expression | Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells. |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:Decreased expression of LY64 has been shown in systemic lupus erythematosus (SLE). The loss of LY64 is associated with B-cell activation and increased disease activity in SLE patients.,Function:May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells.,similarity:Belongs to the Toll-like receptor family.,similarity:Contains 17 LRR (leucine-rich) repeats.,subunit:Binds to MD-1.,tissue specificity:Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells., |
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