Price range: $268.00 through $328.00
Background:Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | CD223 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | 57kD |
| MW(Observed) | 60kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1497R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | LAG3 |
| Protein Name | Lymphocyte activation gene 3 protein |
| Other Name | LAG3; / FDC; / Lymphocyte activation gene 3 protein; / LAG-3; / Protein FDC; / CD223 |
| Species | Human |
| Gene ID | 3902 |
| Uniprot | P18627, |
| Species.1 | Mouse |
| Gene ID.1 | 16768 |
| Uniprot.1 | Q61790, |
| Species.2 | Rat |
| Gene ID.2 | 297596 |
| Uniprot.2 | Q5BK54 |
| Cellular Localization | [Lymphocyte activation gene 3 protein]: Cell membrane; Single-pass type I membrane protein .; [Secreted lymphocyte activation gene 3 protein]: Secreted . Produced following cleavage of the main chain. . |
| Tissue Expression | Primarily expressed in activated T-cells and a subset of natural killer (NK) cells. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Involved in lymphocyte activation. Binds to HLA class-II antigens.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:On cell surface of activated NK and T-lymphocytes., |
