Price range: $268.00 through $328.00
Background：
The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011],
| Size | 50μL/100μL |
| Target | NGFR p75 |
| Reactivity | Human |
| Applications | FC |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | Mouse IgG1/Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | FC:1 µg per million cells in 100 µl volume. For optimal results, the reagent should be titrated according to each specific application |
| Formulation | PBS, pH 7.4 |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Concentration | 0.5mg/ml |
| Clonality | Monoclonal |
| Clone Number | RMMF0119 |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | NGFR |
| Protein Name | Tumor necrosis factor receptor superfamily member 16 |
| Other Name | NGFR; / TNFRSF16; / Tumor necrosis factor receptor superfamily member 16; / Gp80-LNGFR; / Low affinity neurotrophin receptor p75NTR; / Low-affinity nerve growth factor receptor; / NGF receptor; / p75 ICD; / CD antigen CD271 |
| Species | Human |
| Gene ID | 4804 |
| Uniprot | P08138, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9Z0W1, |
| Species.2 | Rat |
| Gene ID.2 | 24596 |
| Uniprot.2 | P07174 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . Perikaryon . Cell projection, growth cone . Cell projection, dendritic spine . |
| Tissue Expression | Brain, |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Apoptosis - multiple species;Organismal Systems >> Nervous system >> Neurotrophin signaling pathway;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> Ras signaling pathway;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction |
| Research Areas | >>MAPK signaling pathway; / >>Ras signaling pathway; / >>Rap1 signaling pathway; / >>Cytokine-cytokine receptor interaction; / >>PI3K-Akt signaling pathway; / >>Apoptosis - multiple species; / >>Neurotrophin signaling pathway; / >>Transcriptional misregulation in cancer |
| Function | Domain:Death domain is responsible for interaction with RANBP9.,Domain:The extracellular domain is responsible for interaction with NTRK1.,Function:Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.,PTM:N- and O-glycosylated.,PTM:O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.,PTM:Phosphorylated on serine residues.,similarity:Contains 1 death domain.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1 (By similarity). Interacts with LINGO1., |
