Product details
Background:This gene encodes a cell surface membrane protein of the immunoglobulin superfamily.This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression ofThis gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient forThis gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest thatThis gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]
