Name: U-Blot® CD3 Mouse mAb
SKU: WM1919
Price: 268 USD
Availability: InStock

U-Blot® CD3 Mouse mAb

Ucallm_WM1919-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WM1919-50

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Product details

Background:The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	CD3E
Reactivity	Human
Applications	FC
MW(Calculated)
MW(Observed)
Host Species	Mouse
Isotype	Mouse IgG1/Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	1 µg per million cells in 100 µl volume. For optimal results, the reagent should be titrated according to each specific application
Formulation	PBS, pH 7.4
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Storage	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Concentration	0.5mg/ml
Clonality	Monoclonal
Clone Number	RMMF0001
Immunogen	Human T cells
Specificity	Endogenous
Gene Name	CD3E T3E
Protein Name	CD3, CD3E
Other Name	T-cell surface glycoprotein CD3 epsilon chain; / T-cell surface antigen T3/Leu-4 epsilon chain; / CD antigen CD3e
Species	Human
Gene ID	916
Uniprot	P07766
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cell membrane
Tissue Expression	Membranous
Signaling_pathway	Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Immune system >> T cell receptor signaling pathway;Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation;Organismal Systems >> Immune system >> Th17 cell differentiation;Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer;Human Diseases >> Immune disease >> Primary immunodeficiency
Research Areas	>>Hematopoietic cell lineage; / >>Th1 and Th2 cell differentiation; / >>Th17 cell differentiation; / >>T cell receptor signaling pathway; / >>Chagas disease; / >>Measles; / >>Human T-cell leukemia virus 1 infection; / >>Epstein-Barr virus infection; / >>Human immunodeficiency virus 1 infection; / >>PD-L1 expression and PD-1 checkpoint pathway in cancer; / >>Primary immunodeficiency
Function