Name: U-Blot® CD30 Rabbit mAb
SKU: WR5212
Price: 268 USD
Availability: InStock

U-Blot® CD30 Rabbit mAb

Ucallm_WR5212-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WR5212-100

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Product details

Background:The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	TNR8
Reactivity	Human
Applications	WB, IHC, IF, ELISA
MW(Calculated)	64kD
MW(Observed)	95kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1446R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	TNFRSF8 CD30 D1S166E
Protein Name	Tumor necrosis factor receptor superfamily member 8 (CD30L receptor) (Ki-1 antigen) (Lymphocyte activation antigen CD30) (CD antigen CD30)
Other Name	Tumor necrosis factor receptor superfamily member 8; / CD30L receptor; / Ki-1 antigen; / Lymphocyte activation antigen CD30; / CD antigen CD30; / TNFRSF8; / CD30; / D1S166E
Species	Human
Gene ID	943
Uniprot	P28908,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q60846,
Species.2	Rat
Gene ID.2
Uniprot.2	P97525
Cellular Localization	[Isoform 1]: Cell membrane; Single-pass type I membrane protein .; [Isoform 2]: Cytoplasm .
Tissue Expression	[Isoform 2]: Detected in alveolar macrophages (at protein level).
Signaling_pathway	Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Research Areas	>>Cytokine-cytokine receptor interaction
Function	Disease:Most specific Hodgkin disease associated antigen.,Function:Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.,PTM:Phosphorylated on serine and tyrosine residues.,similarity:Contains 6 TNFR-Cys repeats.,subunit:Interacts with TRAF1, TRAF2, TRAF3 and TRAF5.,