Product details
Background：
U-Blot® CD366 (Tim-3) Mouse mAb
Ucallm_WM1861-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | TIM 3 |
| Reactivity | Human |
| Applications | FC, IF |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | Mouse IgG1/Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IF 1:200-1:1000; FC:1 µg per million cells in 100 µl volume. For optimal results, the reagent should be titrated according to each specific application |
| Formulation | PBS, pH 7.4 |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Concentration | 0.5mg/ml |
| Clonality | Monoclonal |
| Clone Number | RMMF0116 |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | HAVCR2 TIM3 TIMD3 |
| Protein Name | Hepatitis A virus cellular receptor 2 (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell membrane protein 3) (TIM-3) |
| Other Name | TIM3; / CD366; / TIM-3; / SPTCL; / TIMD3; / Tim-3; / TIMD-3; / HAVcr-2 |
| Species | Human |
| Gene ID | 84868 |
| Uniprot | Q8TDQ0, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8VIM0 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane; Single-pass type I membrane protein . Cell junction . Cell membrane . Localizes to the immunological synapse between CD8+ T-cells and target cells. . |
| Tissue Expression | Expressed in T-helper type 1 (Th1) lymphocytes. Expressed on regulatory T (Treg) cells after TCR stimulation. Expressed in dendritic cells and natural killer (NK) cells. Expressed in epithelial tissues. Expression is increased on CD4+ and CD8+ T-cells in chronic hepatitis C virus (HCV) infection. In progressive HIV-1 infection, expression is up-regulated on HIV-1-specific CD8 T-cells. |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:Genetic variation in HAVCR2 may influence susceptibility to rheumatoid arthritis (RA) [MIM:180300]. RA is an inflammatory disease, primarily of the joints, with autoimmune features and a complex genetic component. It is characterized by inflammation of synovial tissues and the formation of rheumatoid pannus, which is capable of eroding adjacent cartilage and bone, causing subsequent joint destruction.,Function:Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.,similarity:Belongs to the immunoglobulin superfamily. TIM family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,tissue specificity:T-helper type 1 lymphocyte (Th1)-specific., |
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