Price range: $268.00 through $328.00
Background:This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009],
| Size | 50μL/100μL |
| Target | CD326/EPCAM |
| Reactivity | Human |
| Applications | IF, IHC |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | Mouse IgG2b/Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:500-1:1000; ; IF 1:200-1:1000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMMR1473 |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | EPCAM GA733-2 M1S2 M4S1 MIC18 TACSTD1 TROP1 |
| Protein Name | Epithelial cell adhesion molecule |
| Other Name | 17 1A; / 323/A3; / Adenocarcinoma associated antigen; / Adenocarcinoma-associated antigen; / Antigen identified by monoclonal antibody AUA1; / AUA1; / CD326; / CD326 antigen; / Cell surface glycoprotein Trop 1; / Cell surface glycoprotein Trop 2; / Cell surface glycoprotein Trop-1; / CO 17A; / CO17 1A; / CO17A; / DIAR5; / EGP 2; / EGP; / EGP2; / EGP314; / EGP40; / Ep CAM; / Ep-CAM; / EPCAM; / EPCAM_HUMAN; / Epithelial cell adhesion molecule; / Epithelial Cell Adhesion Molecule Intracellular Domain; / EpCAM-ICD; / Epithelial cell surface antigen; / Epithelial cellular adhesion molecule; / Epithelial glycoprotein 1; / Epithelial glycoprotein 314; / Epithelial glycoprotein; / ESA; / GA733 1; / GA733 2; / GA733-2; / gastrointestinal tumor-associated antigen 2; / 35-KD glycoprotein; / hEGP 2; / hEGP314; / HNPCC8; / Human epithelial glycoprotein 2; / KS 1/4 antigen; / KS1/4; / KSA; / Lymphocyte antigen 74; / M1S 1; / M1S2; / M4S1; / Major gastrointestinal tumor associated protein GA733 2; / Major gastrointestinal tumor-associated protein GA733-2; / Membrane component chromosome 4 surface marker; / 35kD glycoprotein; / Membrane component; / chromosome 4; / surface marker 1; / Membrane component; / chromosome 4; / surface marker; / MIC18; / MK 1; / TACD1; / TACSTD1; / TROP1; / Tumor associated calcium signal transducer 1; / Tumor associated calcium signal transducer 2 precursor; / Tumor-associated calcium signal transducer 1; / CD326 nanobody; / EPCAM nanobody |
| Species | Human |
| Gene ID | 7056 |
| Uniprot | P16422 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Lateral cell membrane; Single-pass type I membrane protein . Cell junction, tight junction . Colocalizes with CLDN7 at the lateral cell membrane and tight junction. . |
| Tissue Expression | Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma. |
| Signaling_pathway | Organismal Systems >> Immune system >> Complement and coagulation cascades |
| Research Areas | |
| Function |
