Name: U-Blot® CD62L Mouse mAb
SKU: WM1895
Price: 268 USD
Availability: InStock

U-Blot® CD62L Mouse mAb

Ucallm_WM1895-50

Price range: $268.00 through $328.00

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50μl

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SKU: WM1895-50

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Product details

Background:CD62L is a 74-95 kD single chain type I glycoprotein referred to as L-selectin or LECAM-1. It is expressed on most peripheral blood B cells, subsets of T and NK cells, monocytes, granulocytes, and certain hematopoietic malignant cells. CD62L binds to carbohydrates present on certain glycoforms of CD34, glycam-1, and MAdCAM-1 and with a low affinity to anionic oligosaccharide sequences related to sialylated Lewis X (sLex, CD15s) through its C-type lectin domain. CD62L is important for the homing of na?ve lymphocytes to high endothelial venules in peripheral lymph nodes and Peyer’s patches. It also plays a role in leukocyte rolling on activated endothelial cells.

Specifications

Target	CD62L
Reactivity	Human
Applications	FC, IF
MW(Calculated)
MW(Observed)
Host Species	Mouse
Isotype	Mouse IgG2a,Kappa
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	IF 1:200-1:1000; FC:1 µg per million cells in 100 µl volume. For optimal results, the reagent should be titrated according to each specific application
Formulation	PBS, pH 7.4
Source
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Purity
Storage	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Concentration	0.5mg/ml
Clonality	Monoclonal
Clone Number	PTF0128
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Sequence
Specificity	Endogenous
Gene Name	SELL LNHR LYAM1
Protein Name	L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L)
Other Name	TQ1; / LAM1; / LEU8; / LNHR; / LSEL; / CD62L; / LYAM1; / PLNHR; / LECAM1; / L-selectin; / LECAM-1; / SELL; / LAM-1; / TQ-1; / MEL-14; / CD62L nanobody
Species	Human
Gene ID	6402
Uniprot	P14151
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Organism-4
GeneID-4
SwissProt-4
Cellular Localization	Cell membrane; Single-pass type I membrane protein .
Tissue Expression	Expressed in B-cell lines and T-lymphocytes.
Signaling_pathway	Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules
Research Areas
Function	Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28489325, PubMed:28011641).Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641).
RRID