Name: U-Blot® CLEC7A Rabbit mAb
SKU: WR5162
Price: 268 USD
Availability: InStock

U-Blot® CLEC7A Rabbit mAb

Ucallm_WR5162-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WR5162-100

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Product details

Background:This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	CLEC7A
Reactivity	Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)	28kD
MW(Observed)	36,45kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1396R
Immunogen	The antiserum was produced against synthesized peptide derived from human CLEC7A. AA range:1-44
Specificity	Endogenous
Gene Name	CLEC7A BGR CLECSF12 DECTIN1 UNQ539/PRO1082
Protein Name	C-type lectin domain family 7 member A (Beta-glucan receptor) (C-type lectin superfamily member 12) (Dendritic cell-associated C-type lectin 1) (DC-associated C-type lectin 1) (Dectin-1)
Other Name
Species	Human
Gene ID	64581
Uniprot	Q9BXN2,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q6QLQ4
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cell membrane; Single-pass type II membrane protein .; [Isoform 5]: Cytoplasm .; [Isoform 6]: Cytoplasm .; [Isoform 7]: Cytoplasm .
Tissue Expression	Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta.
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Phagosome;Organismal Systems >> Immune system >> Neutrophil extracellular trap formation
Research Areas	>>Phagosome; / >>Neutrophil extracellular trap formation; / >>C-type lectin receptor signaling pathway; / >>Tuberculosis
Function	Function:Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation.,induction:Up-regulated during differentiation from monocytes into dendritic cells.,PTM:Phosphorylated on tyrosine residues in response to glucan binding.,similarity:Contains 1 C-type lectin domain.,subunit:Isoform 5 interacts with RANBP9.,tissue specificity:Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta.,