Name: U-Blot® DDC Rabbit mAb
SKU: WR5242
Price: 268 USD
Availability: InStock

U-Blot® DDC Rabbit mAb

Ucallm_WR5242-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WR5242-100

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Product details

Background:dopa decarboxylase(DDC) Homo sapiens The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011],

Specifications

Size	50μL/100μL
Target	DDC
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, IP, ELISA
MW(Calculated)	54kD
MW(Observed)	54kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:500-1:2000; WB 1:1000-1:20000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1481R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	DDC AADC
Protein Name	Aromatic-L-amino-acid decarboxylase (AADC) (DOPA decarboxylase) (DDC)
Other Name
Species	Human
Gene ID	1644
Uniprot	P20711,
Species.1	Mouse
Gene ID.1
Uniprot.1	O88533,
Species.2	Rat
Gene ID.2
Uniprot.2	P14173
Cellular Localization	cytosol,synaptic vesicle,axon,neuronal cell body,extracellular exosome,
Tissue Expression	[Isoform 2]: High expression in kidney.
Signaling_pathway	Organismal Systems >> Nervous system >> Dopaminergic synapse
Research Areas	>>Tyrosine metabolism; / >>Phenylalanine metabolism; / >>Tryptophan metabolism; / >>Metabolic pathways; / >>Serotonergic synapse; / >>Dopaminergic synapse; / >>Cocaine addiction; / >>Amphetamine addiction; / >>Alcoholism
Function	Catalytic activity:3,4-dihydroxy-L-phenylalanine = dopamine + CO(2).,Catalytic activity:5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO(2).,cofactor:Pyridoxal phosphate.,Disease:Defects in DDC are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD) [MIM:608643]. AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive.,Function:Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.,online information:Aromatic L-amino-acid decarboxylase entry,pathway:Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2.,similarity:Belongs to the group II decarboxylase family.,subunit:Homodimer.,