U-Blot® DYL1 Rabbit mAb
Ucallm_WR6067-50
Price range: $268.00 through $328.00
Product details
Background：
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1 ,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains , and stalks linking the heads to a basal domain , which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer , a conformation necessary for activity , and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq , Jul 2008] ,
Specifications
| Size | 50μL/100μL |
| Target | DYL1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | 10kD |
| MW(Observed) | 10kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1947R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1 |
| Protein Name | DYL1 |
| Other Name | |
| Species | Human |
| Gene ID | 8655 |
| Uniprot | P63167, |
| Species.1 | Mouse |
| Gene ID.1 | 56455 |
| Uniprot.1 | P63168, |
| Species.2 | Rat |
| Gene ID.2 | 58945 |
| Uniprot.2 | P63170 |
| Cellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton . Nucleus . Mitochondrion . Upon induction of apoptosis translocates together with BCL2L11 to mitochondria. . |
| Tissue Expression | Ubiquitous (PubMed:8628263). Expressed in testis (PubMed:22965910). |
| Signaling_pathway | |
| Research Areas | >>Vasopressin-regulated water reabsorption; / >>Salmonella infection |
| Function | Function:Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.,Function:May be involved in some aspects of dynein-related intracellular transport and motility. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.,similarity:Belongs to the dynein light chain family.,subunit:Consists of at least two heavy chains and a number of intermediate and light chains. Interacts with rabies P protein (By similarity). Interacts with TXNDC17.,tissue specificity:Ubiquitous., |
Please login to post questions
Related products
