U-Blot® EphB3 Rabbit mAb
Ucallm_WR6003-50
Price range: $268.00 through $328.00
Product details
Background：
Ephrin receptors and their ligands , the ephrins , mediate numerous developmental processes , particularly in the nervous system. Based on their structures and sequence relationships , ephrins are divided into the ephrin-A (EFNA) class , which are anchored to the membrane by a glycosylphosphatidylinositol linkage , and the ephrin-B (EFNB) class , which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq , Mar 2010] ,
Specifications
| Size | 50μL/100μL |
| Target | EphB3 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | 110kD |
| MW(Observed) | 120kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1999R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | EPHB3 ETK2 HEK2 TYRO6 |
| Protein Name | Ephrin type-B receptor 3 |
| Other Name | EPHB3; / ETK2; / HEK2; / TYRO6; / Ephrin type-B receptor 3; / EPH-like tyrosine kinase 2; / EPH-like kinase 2; / Embryonic kinase 2; / EK2; / hEK2; / Tyrosine-protein kinase TYRO6 |
| Species | Human |
| Gene ID | 2049 |
| Uniprot | P54753, |
| Species.1 | Mouse |
| Gene ID.1 | 13845 |
| Uniprot.1 | P54754 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . Cell projection, dendrite . |
| Tissue Expression | Ubiquitous. |
| Signaling_pathway | |
| Research Areas | >>Axon guidance |
| Function | Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Function:Receptor for members of the ephrin-B family. Binds to ephrin-B1 and -B2.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,tissue specificity:Ubiquitous., |
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