Price range: $268.00 through $328.00
Background：
This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis , catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq , Jul 2008] ,
| Size | 50μL/100μL |
| Target | FDFT |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | 48kD |
| MW(Observed) | 48kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1981R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | FDFT1 |
| Protein Name | FDFT |
| Other Name | |
| Species | Human |
| Gene ID | 2222 |
| Uniprot | P37268, |
| Species.1 | Mouse |
| Gene ID.1 | 14137 |
| Uniprot.1 | P53798, |
| Species.2 | Rat |
| Gene ID.2 | 29580 |
| Uniprot.2 | Q02769 |
| Cellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein . |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | |
| Research Areas | >>Steroid biosynthesis; / >>Metabolic pathways |
| Function | Catalytic activity:2 farnesyl diphosphate = diphosphate + presqualene diphosphate.,Catalytic activity:Presqualene diphosphate + NAD(P)H = squalene + diphosphate + NAD(P)(+).,cofactor:Magnesium.,pathway:Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl-PP: step 1/3.,similarity:Belongs to the phytoene/squalene synthetase family.,subunit:Monomer., |
