U-Blot® Granulin Rabbit mAb
Ucallm_WR5077-50
Price range: $268.00 through $328.00
Product details
Background:disease:Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.,function:Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.,function:Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.,PTM:Granulins are disulfide bridged.,similarity:Belongs to the granulin family.,tissue specificity:In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.,
Specifications
| Size | 50μL/100μL |
| Target | Progranulin |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | 64kD |
| MW(Observed) | 88kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1318R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | GRN |
| Protein Name | Progranulin |
| Other Name | Granulins; / Proepithelin; / PEPI; / [Cleaved into: Acrogranin; / Paragranulin; / Granulin-1; / Granulin G; / Granulin-2; / Granulin F; / Granulin-3; / Granulin B; / Granulin-4; / Granulin A; / Granulin-5; / Granulin C; / Granulin-6; / Granulin D; / Granulin-7; / Granulin E; / ] |
| Species | Human |
| Gene ID | 2896 |
| Uniprot | P28799, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P28798, |
| Species.2 | Rat |
| Gene ID.2 | 29143 |
| Uniprot.2 | P23785 |
| Cellular Localization | Secreted . Lysosome . Endocytosed by SORT1 and delivred to lysosomes (PubMed:21092856, PubMed:28073925). Targeted to lysosome by PSAP via M6PR and LRP1, in both biosynthetic and endocytic pathways (PubMed:26370502, PubMed:28073925). Co-localized with GBA in the intracellular trafficking compartments until to lysosome (By similarity). . |
| Tissue Expression | In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney. |
| Signaling_pathway | |
| Research Areas | |
| Function | in utero embryonic development, blastocyst development, blastocyst hatching, female pregnancy, embryo implantation, positive regulation of cell proliferation, embryonic development ending in birth or egg hatching, hatching,regulation of cell proliferation, chordate embryonic development, regulation of epithelial cell proliferation, positive regulation of epithelial cell proliferation, |
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