Product details
Background:Histone H3 forms H3-H4 tetramers as nucleosome core scaffold. Lysine dimethylation is a reversible epigenetic modification controlled by methyltransferases and demethylases. Different dimethyl marks recruit specific reader proteins to regulate poised transcription, heterochromatin formation, DNA repair and cell differentiation. Each lysine site on H3 carries unique biological functions. H3K18me2 mainly locates at super-enhancers of pluripotent cells. It restricts excessive transcription and safeguards cell identity during lineage differentiation. Abnormal reduction of H3K18me2 drives uncontrolled tumor cell proliferation.
