Name: U-Blot® IRF-4/MUM1 Rabbit mAb (Ready to Use)
SKU: WR8079
Price: 168 USD
Availability: InStock

U-Blot® IRF-4/MUM1 Rabbit mAb (Ready to Use)

Ucallm_WR8079

$168.00

Product details

Background：
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010],

Specifications

Target	MUM1
Reactivity	Human
Applications	IHC
MW(Calculated)
MW(Observed)
Host Species	Rabbit
Isotype	IgG1,Kappa
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	Ready to use for IHC / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation	The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
Source
Purification	Recombinant Expression and Affinity purified
Purity
Storage	2°C to 8°C/1 year,Ship by ice bag
Concentration
Clonality	Monoclonal
Clone Number	ABT249R9
Immunogen	Synthesized peptide derived from human MUM1 AA range:350-451
Sequence
Specificity	This antibody detects endogenous levels of MUM1
Gene Name	IRF4 MUM1
Protein Name	Interferon regulatory factor 4
Other Name	Interferon regulatory factor 4; / IRF 4; / IRF-4; / Irf4; / IRF4_HUMAN; / LSIRF; / Lymphocyte specific interferon regulatory factor; / Lymphocyte specific IRF; / Lymphocyte-specific interferon regulatory factor; / Multiple myeloma oncogene 1; / MUM 1; / MUM1; / NF EM5; / NF-EM5; / NFEM5; / PU.1 interaction partner; / Sfpi1/PU.1 interaction partner; / Transcriptional activator PIP
Species	Human
Gene ID-1	3662
Uniprot	Q15306
Species.1
Gene ID-2
Uniprot.1
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6; 14)(p25; q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010],
Cellular Localization	Nuclear
Tissue Expression	Lymphoid cells.
Signaling_pathway	Organismal Systems >> Immune system >> Th17 cell differentiation
Research Areas	>>Th17 cell differentiation
Function	Disease:A chromosomal aberration involving IRF4 may be a cause of multiple myeloma [MIM:254500]. Translocation t(6; 14)(p25; q32) with the IgH locus.,Function:Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.,induction:Not induced by interferons.,similarity:Belongs to the IRF family.,similarity:Contains 1 tryptophan pentad repeat DNA-binding domain.,subunit:Interacts with SPIB and DEF6.,tissue specificity:Lymphoid cells.,
RRID