Price range: $268.00 through $328.00
Background：
The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq , Jul 2008] ,
| Size | 50μL/100μL |
| Target | MAOB |
| Reactivity | Human |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 59kD |
| MW(Observed) | 62kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1862R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | MAOB |
| Protein Name | Amine oxidase [flavin-containing] B (Monoamine oxidase type B) (MAO-B) |
| Other Name | |
| Species | Human |
| Gene ID | 4129 |
| Uniprot | P27338, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8BW75, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P19643 |
| Cellular Localization | Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side. |
| Tissue Expression | Brain, |
| Signaling_pathway | Organismal Systems >> Nervous system >> Dopaminergic synapse;Human Diseases >> Neurodegenerative disease >> Parkinson disease |
| Research Areas | >>Glycine, serine and threonine metabolism; / >>Arginine and proline metabolism; / >>Histidine metabolism; / >>Tyrosine metabolism; / >>Phenylalanine metabolism; / >>Tryptophan metabolism; / >>Drug metabolism - cytochrome P450; / >>Metabolic pathways; / >>Serotonergic synapse; / >>Dopaminergic synapse; / >>Parkinson disease; / >>Cocaine addiction; / >>Amphetamine addiction; / >>Alcoholism |
| Function | Catalytic activity:RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2).,cofactor:FAD.,Function:Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.,mass spectrometry: PubMed:11049757,online information:Monoamine oxidase entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the flavin monoamine oxidase family.,subunit:Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer., |
