Name: U-Blot® ME3 Rabbit mAb
SKU: WR5372
Price: 268 USD
Availability: InStock

U-Blot® ME3 Rabbit mAb

Ucallm_WR5372-50

Price range: $268.00 through $328.00

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SKU: WR5372-50

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Product details

Background:Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008],

Specifications

Target	ME3
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)	67kD
MW(Observed)	60kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	PT1616R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Sequence
Specificity	Endogenous
Gene Name	ME3
Protein Name	NADP-dependent malic enzyme mitochondrial
Other Name	ME3; / NADP-dependent malic enzyme; / mitochondrial; / NADP-ME; / Malic enzyme 3
Species	Human
Gene ID-1	10873
Uniprot	Q16798,
Species.1	Mouse
Gene ID-2	109264
Uniprot.1	Q8BMF3
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008],
Cellular Localization	Mitochondrion matrix.
Tissue Expression	Expressed predominantly in organs with a low-division rate.
Signaling_pathway	Organismal Systems >> Endocrine system >> PPAR signaling pathway
Research Areas	>>Pyruvate metabolism; / >>Metabolic pathways; / >>Carbon metabolism; / >>PPAR signaling pathway
Function	Catalytic activity:(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH.,cofactor:Divalent metal cations. Prefers magnesium or manganese.,similarity:Belongs to the malic enzymes family.,tissue specificity:Expressed predominantly in organs with a low-division rate.,
RRID

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U-Blot® ME3 Rabbit mAb

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U-Blot® ME3 Rabbit mAb

Product details

Specifications

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