U-Blot® mGluR2 Rabbit mAb
Ucallm_WR5959-50
Price range: $268.00 through $328.00
Product details
Background：
glutamate metabotropic receptor 2 (GRM2) Homo sapiens L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors , that have been divided into 3 groups on the basis of sequence homology , putative signal transduction mechanisms , and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4 , GRM6 , GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene
Specifications
| Size | 50μL/100μL |
| Target | mGluR2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 99kD |
| MW(Observed) | >200kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1927R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | GRM2 |
| Protein Name | Metabotropic glutamate receptor 2 |
| Other Name | GRM2; / GPRC1B; / MGLUR2; / Metabotropic glutamate receptor 2; / mGluR2 |
| Species | Human |
| Gene ID | 2912 |
| Uniprot | Q14416, |
| Species.1 | Mouse |
| Gene ID.1 | 108068 |
| Uniprot.1 | Q14BI2, |
| Species.2 | Rat |
| Gene ID.2 | 24415 |
| Uniprot.2 | P31421 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. Cell junction, synapse . Cell projection, dendrite . |
| Tissue Expression | Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain. |
| Signaling_pathway | Organismal Systems >> Nervous system >> Glutamatergic synapse;Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway |
| Research Areas | >>Phospholipase D signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Glutamatergic synapse; / >>Cocaine addiction |
| Function | Function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.,similarity:Belongs to the G-protein coupled receptor 3 family.,subunit:Interacts with GRASP.,tissue specificity:Widely expressed in different regions of the adult brain as well as in fetal brain., |
Please login to post questions
Related products
