Specifications
| Size | 50μL/100μL |
| Target | MKP-3 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | 42kD |
| MW(Observed) | 42kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1736R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | DUSP6 |
| Protein Name | Dual specificity protein phosphatase 6 |
| Other Name | DUSP6; / MKP3; / PYST1; / Dual specificity protein phosphatase 6; / Dual specificity protein phosphatase PYST1; / Mitogen-activated protein kinase phosphatase 3; / MAP kinase phosphatase 3; / MKP-3 |
| Species | Human |
| Gene ID | 1848 |
| Uniprot | Q16828, |
| Species.1 | Mouse |
| Gene ID.1 | 67603 |
| Uniprot.1 | Q9DBB1, |
| Species.2 | Rat |
| Gene ID.2 | 116663 |
| Uniprot.2 | Q64346 |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | Expressed in keratinocytes (at protein level). |
| Signaling_pathway | Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Cancer: specific types >> Acute myeloid leukemia;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway |
| Research Areas | >>MAPK signaling pathway; / >>Transcriptional misregulation in cancer; / >>Acute myeloid leukemia |
| Function | Catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,Catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,Function:Inactivates MAP kinases. Has a specificity for the ERK family.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.,similarity:Contains 1 rhodanese domain.,similarity:Contains 1 tyrosine-protein phosphatase domain., |
