Specifications
| Size | 50μL/100μL |
| Target | NDRG2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | 41kD |
| MW(Observed) | 47kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1767R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | NDRG2 |
| Protein Name | Protein NDRG2 |
| Other Name | NDRG2; / KIAA1248; / SYLD; / Protein NDRG2; / N-myc downstream-regulated gene 2 protein; / Protein Syld709613 |
| Species | Human |
| Gene ID | 57447 |
| Uniprot | Q9UN36, |
| Species.1 | Mouse |
| Gene ID.1 | 29811 |
| Uniprot.1 | Q9QYG0, |
| Species.2 | Rat |
| Gene ID.2 | 171114 |
| Uniprot.2 | Q8VBU2 |
| Cellular Localization | Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone . In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity). . |
| Tissue Expression | Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level). |
| Signaling_pathway | |
| Research Areas | |
| Function | developmental stage:Specifically expressed during dendritic cell differentiation (in vitro). Expression is low in fetal brain and increases during brain postnatal development.,Disease:Found in pathological brain lesions of Alzheimer disease.,Disease:Not expressed or strongly down-regulated in various cancer types, such as astrocytoma, meningioma, liver cancer and pancreatic cancer.,Function:May be involved in dendritic cell and neuron differentiation. May have anti-tumor activity.,similarity:Belongs to the NDRG family.,subcellular location:Perinuclear in neurons.,tissue specificity:Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Generally not expressed in tumor cell lines. Isoforms 1 and 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level)., |
