Price range: $268.00 through $328.00
Background:function:Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.,PTM:N-glycosylated.,PTM:O-glycosylated.,similarity:Belongs to the natural cytotoxicity receptor (NCR) family.,similarity:Contains 2 Ig-like (immunoglobulin-like) domains.,subunit:Interacts with CD3Z and FCER1G.,tissue specificity:Selectively expressed by both resting and activated NK cells.,
| Size | 50μL/100μL |
| Target | NKp46 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 34kD |
| MW(Observed) | 50-60kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1574R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | NCR1 |
| Protein Name | Natural cytotoxicity triggering receptor 1 |
| Other Name | NCR1; / LY94; / Natural cytotoxicity triggering receptor 1; / Lymphocyte antigen 94 homolog; / NK cell-activating receptor; / Natural killer cell p46-related protein; / NK-p46; / NKp46; / hNKp46; / CD antigen CD335 |
| Species | Human |
| Gene ID | 9437 |
| Uniprot | O76036, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8C567 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . |
| Tissue Expression | Selectively expressed by both resting and activated NK cells. |
| Signaling_pathway | Organismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity |
| Research Areas | >>Natural killer cell mediated cytotoxicity |
| Function | Function:Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.,PTM:N-glycosylated.,PTM:O-glycosylated.,similarity:Belongs to the natural cytotoxicity receptor (NCR) family.,similarity:Contains 2 Ig-like (immunoglobulin-like) domains.,subunit:Interacts with CD3Z and FCER1G.,tissue specificity:Selectively expressed by both resting and activated NK cells., |
