U-Blot® OPTN rabbit pAb
Ucallm_WP25039-50
Price range: $268.00 through $328.00
Product details
Background：
Specifications
| Size | 50μL/100μL |
| Target | OPTN |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 65kD,42kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human OPTN |
| Specificity | This antibody detects endogenous levels of OPTN at Human, Mouse,Rat |
| Gene Name | OPTN FIP2 GLC1E HIP7 HYPL NRP |
| Protein Name | OPTN |
| Other Name | Optineurin; / E3-14.7K-interacting protein; / FIP-2; / Huntingtin yeast partner L; / Huntingtin-interacting protein 7; / HIP-7; / Huntingtin-interacting protein L; / NEMO-related protein; / Optic neuropathy-inducing protein; / Transcription factor IIIA-interacting protein; / TFIIIA-IntP |
| Species | Human |
| Gene ID | 10133 |
| Uniprot | Q96CV9, |
| Species.1 | Mouse |
| Gene ID.1 | 71648 |
| Uniprot.1 | Q8K3K8, |
| Species.2 | Rat |
| Gene ID.2 | 246294 |
| Uniprot.2 | Q8R5M4 |
| Cellular Localization | Cytoplasm, perinuclear region. Golgi apparatus . Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle. Recycling endosome. Found in the perinuclear region and associates with the Golgi apparatus (PubMed:27534431). Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane. Localizes to LC3-positive cytoplasmic vesicles upon induction of autophagy. . |
| Tissue Expression | Present in aqueous humor of the eye (at protein level). Highly expressed in trabecular meshwork. Expressed nonpigmented ciliary epithelium, retina, brain, adrenal cortex, fetus, lymphocyte, fibroblast, skeletal muscle, heart, liver, brain and placenta. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Autophagy - animal;Cellular Processes >> Transport and catabolism >> Mitophagy - animal;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases |
| Research Areas | >>Mitophagy - animal; / >>Amyotrophic lateral sclerosis; / >>Pathways of neurodegeneration - multiple diseases |
| Function |
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