U-Blot® P2RX7 Rabbit mAb
Ucallm_WR5791-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | P2RX7 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 69kD |
| MW(Observed) | 80kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1754R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | P2RX7 |
| Protein Name | P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor) |
| Other Name | P2X purinoceptor 7; / P2X7; / ATP receptor; / P2Z receptor; / Purinergic receptor |
| Species | Human |
| Gene ID | 5027 |
| Uniprot | Q99572, |
| Species.1 | Mouse |
| Gene ID.1 | 18439 |
| Uniprot.1 | Q9Z1M0, |
| Species.2 | Rat |
| Gene ID.2 | 29665 |
| Uniprot.2 | Q64663 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . |
| Tissue Expression | Widely expressed with highest levels in brain and immune tissues. |
| Signaling_pathway | Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway |
| Research Areas | |
| Function | Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells . |
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