U-Blot® Phospho-CD31 (Tyr713) Rabbit mAb
Ucallm_WT9064-100
Price range: $288.00 through $368.00
Product details
Background:CD31, also named as Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1), a member of the Ig superfamily of cell adhesion molecules, is expressed by circulating platelets, monocytes, neutrophils, some T cells, and endothelial cells and modulates cell adhesion, endothelial cell migration, and angiogenesis. CD31 is phosphorylated on Tyr686 at the cytoplasmic carboxy-terminal tail upon various stimuli (e.g. mechanical or oxidative stress), presumably by Src family members. The tyrosine phosphorylation mediates associations with a number of SH2 domain-containing binding partners such as PI3 kinase, SHIP, PLCγ, and SHP 2. Thus, CD31 serves as a scaffold for various signaling molecules.
Specifications
| Target | Phospho-CD31 (Tyr713) |
| Reactivity | Human |
| Application | WB |
| MW(Calculated) | 83 kDa |
| MW(Observed) | 130 kDa |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Modification | Phosphorylation |
| Modification Site | Tyr713 |
| Recommended dilution ratio | WB 1:1000 |
| Composition | PBS, Glycerol, BSA |
| Purification process | Protein A affinity purification |
| Storage | Store at -20°C. Avoid repeated freeze-thaw cycles |
| Stability | Stable for 12 months from date of receipt / reconstitution. |
| Concentration | |
| Clonal | Recombinant monoclonal |
| Clone Number | W-R38 |
| Immunogen | polypeptide |
| Gene Name | PECAM1 |
| Protein Name | Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) |
| Alternative name | CD31, PECAM1 |
| Organism-1 | Human |
| Gene ID | 5175 |
| SwissProt-1 | P16284 |
| Cellular Localization | Membrane |
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