Name: U-Blot® Podoplanin Mouse mAb (Ready to Use)
SKU: WM1572R
Price: 168 USD
Availability: InStock

Product details

Background：
This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],

Specifications

Target	Podoplanin
Reactivity	Human
Applications	IHC
MW(Calculated)
MW(Observed)
Host Species	Mouse
Isotype	IgG1,Kappa
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	Ready to use for IHC / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation	The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
Source
Purification	The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Purity
Storage	2°C to 8°C/1 year,Ship by ice bag
Concentration
Clonality	Monoclonal
Clone Number	ABT513
Immunogen	Synthesized peptide derived from human Podoplanin AA range: 23-100
Sequence
Specificity	The antibody can specifically recognize human Podoplanin protein.
Gene Name	PDPN GP36 PSEC0003 PSEC0025
Protein Name	Aggrus Glycoprotein 36 Gp36 PA2.26 antigen T1-alpha T1A
Other Name	Podoplanin; / Aggrus; / Glycoprotein 36; / Gp36; / PA2.26 antigen; / T1-alpha; / T1A
Species	Human
Gene ID-1	10630
Uniprot	Q86YL7,
Species.1	Mouse
Gene ID-2	14726
Uniprot.1	Q62011,
Species.2	Rat
Gene ID-3	54320
Uniprot.2	Q64294
Organism-4
Gene ID-4
SwissProt-4
Background	This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
Cellular Localization	Cytoplasmic
Tissue Expression	Tonsil/ Appendix
Signaling_pathway
Research Areas
Function	Caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,Function:May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.,PTM:Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity.,PTM:The N-terminus is blocked.,similarity:Belongs to the podoplanin family.,subcellular location:Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles.,tissue specificity:Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.,
RRID