Price range: $268.00 through $328.00
Background：
This gene is a member of the largest group in the Ras superfamily of small GTPases , which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq , Dec 2012] ,
| Size | 50μL/100μL |
| Target | RAB4A |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | 24kD |
| MW(Observed) | 24kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:20-1:50; WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM2016R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | rab4a-n |
| Protein Name | |
| Other Name | HRES 1 / RAB4; / Oncogene RAB4; / OTTHUMP00000042824; / Rab 4; / RAB 4A; / RAB4 member RAS oncogene family; / RAB4A; / RAB4A member RAS oncogene family; / RAB4A_HUMAN; / Ras related protein Rab 4A; / Ras related protein Rab4A; / Ras-related protein Rab-4A. |
| Species | Human |
| Gene ID | 5867 |
| Uniprot | P20338, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P56371 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane; Peripheral membrane protein . Cytoplasm . Early endosome membrane; Peripheral membrane protein . Recycling endosome membrane; Peripheral membrane protein . Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1. . |
| Tissue Expression | Brain,Caudate nucleus,Cervix carcinoma,Human small intestine,Skin,U |
| Signaling_pathway | |
| Research Areas | >>Endocytosis |
| Function | Function:Protein transport. Probably involved in vesicular traffic.,PTM:Phosphorylated by CDC2 kinase during mitosis.,similarity:Belongs to the small GTPase superfamily. Rab family.,subcellular location:Generally associated with membranes. Cytoplasmic when phosphorylated by CDC2.,subunit:Interacts with RAB11FIP1, RABEP1, ZFYVE20 and RUFY1. Interacts with SGSM1, SGSM2 and SGSM3., |
