Name: U-Blot® RARβ Rabbit mAb
SKU: WR6059
Price: 268 USD
Availability: InStock

U-Blot® RARβ Rabbit mAb

Ucallm_WR6059-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WR6059-50

Enter the quantity you would like, or drag the panel to find the quantity and price that best for you

Bulk Quote Authorize OEM & ODM

Product details

Background：
This gene encodes retinoic acid receptor beta , a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid , the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis , cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq , Mar 2014] ,

Specifications

Size	50μL/100μL
Target	RARβ
Reactivity	Human
Applications	WB, IHC, IF, ELISA
MW(Calculated)	51kD
MW(Observed)	58kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM2015R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	RARB
Protein Name	Retinoic acid receptor beta
Other Name	RARB; / HAP; / NR1B2; / Retinoic acid receptor beta; / RAR-beta; / HBV-activated protein; / Nuclear receptor subfamily 1 group B member 2; / RAR-epsilon
Species	Human
Gene ID	5915
Uniprot	P10826,
Species.1	Mouse
Gene ID.1	218772
Uniprot.1	P22605
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nucleus . Cytoplasm .; [Isoform Beta-1]: Nucleus.; [Isoform Beta-2]: Nucleus.; [Isoform Beta-4]: Cytoplasm.
Tissue Expression	Expressed in aortic endothelial cells (at protein level).
Signaling_pathway	Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Gastric cancer;Human Diseases >> Cancer: specific types >> Small cell lung cancer;Human Diseases >> Cancer: specific types >> Non-small cell lung cancer
Research Areas	>>Pathways in cancer; / >>Small cell lung cancer; / >>Non-small cell lung cancer; / >>Gastric cancer
Function	Domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,Function:This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell function by directly regulating gene expression.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,