U-Blot® Research Grade Anselamimab
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$9,999.00
Product details
Background：Anselamimab (CAEL-101) a humanized IgG1-κ anti-Amyloid fibrils antibody targeting to serum amyloid A1 (SAA1).
• Overexpression of serum amyloid a 1 induces depressive-like behavior in mice., PMID:27608955
• Pathogenic serum amyloid A 1.1 shows a long oligomer-rich fibrillation lag phase contrary to the highly amyloidogenic non-pathogenic SAA2.2., PMID:23223242
• Serum amyloid A levels are associated with polymorphic variants in the serum amyloid A 1 and 2 genes., PMID:30852808
• Large-scale isotype-specific quantification of Serum amyloid A 1/2 by multiple reaction monitoring in crude sera., PMID:22300576
• Increased susceptibility of serum amyloid A 1.1 to degradation by MMP-1: potential explanation for higher risk of type AA amyloidosis., PMID:18815155
• Diversity and complexity of the mouse Saa1 and Saa2 genes., PMID:24521869
• The role of PPAR activation during the systemic response to brain injury., PMID:25994490
• Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A., PMID:20890286
• Hematological and acute-phase responses to diet-induced obesity in IL-6 KO mice., PMID:21996012
• Clustering of six human 11p15 gene homologs within a 500-kb interval of proximal mouse chromosome 7., PMID:7698755
Specifications
| Target | SAA |
| Reactivity | Human |
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Chimeric |
| Isotype | IgG1-kappa |
| Conjugate/Modification | |
| Modification | |
| Recommended Dilution Ratio | |
| Composition | 0.01M PBS, pH 7.4. |
| Purification Process | Protein A/G purified from cell culture supernatant. |
| Purity | >95% purity as determined by SDS-PAGE. |
| Storage Condition | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | |
| Immunogen | Mammalian Cells |
| Gene Name | |
| Protein Name | |
| Alias | SAA, Serum amyloid A-1 protein, SAA1, Amyloid fibril protein AA |
| Species | |
| Gene ID-1 | P0DJI8 |
| Uniprot | |
| Species.1 | |
| Gene ID | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.1 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Description | Background：Anselamimab (CAEL-101) a humanized IgG1-κ anti-Amyloid fibrils antibody targeting to serum amyloid A1 (SAA1).<br>• Overexpression of serum amyloid a 1 induces depressive-like behavior in mice., PMID:27608955<br />• Pathogenic serum amyloid A 1.1 shows a long oligomer-rich fibrillation lag phase contrary to the highly amyloidogenic non-pathogenic SAA2.2., PMID:23223242<br />• Serum amyloid A levels are associated with polymorphic variants in the serum amyloid A 1 and 2 genes., PMID:30852808<br />• Large-scale isotype-specific quantification of Serum amyloid A 1/2 by multiple reaction monitoring in crude sera., PMID:22300576<br />• Increased susceptibility of serum amyloid A 1.1 to degradation by MMP-1: potential explanation for higher risk of type AA amyloidosis., PMID:18815155<br />• Diversity and complexity of the mouse Saa1 and Saa2 genes., PMID:24521869<br />• The role of PPAR activation during the systemic response to brain injury., PMID:25994490<br />• Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A., PMID:20890286<br />• Hematological and acute-phase responses to diet-induced obesity in IL-6 KO mice., PMID:21996012<br />• Clustering of six human 11p15 gene homologs within a 500-kb interval of proximal mouse chromosome 7., PMID:7698755<br /> |
| Cellular Localization | |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function |
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