Name: U-Blot® Research Grade Brolucizumab
SKU: WA2557
Price: 9999 USD
Availability: InStock

Product details

Background：Suvemcitug is a humanized IgG1κ antibody targeting VEGF derived from the African hare (Oryctolagus cuniculus).
• Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy., PMID:12409337
• Vascular endothelial growth factor and its receptors., PMID:7515293
• Tumors: wounds that do not heal-redux., PMID:25568067
• Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis., PMID:12461084
• Differential expression of vascular endothelial growth factor (vascular permeability factor) forms in rat tissues., PMID:8527159
• Hypoxia regulates the expression of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) and its receptors in human skin., PMID:9036922
• Synthesis, storage, and release of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) by human mast cells: implications for the biological significance of VEGF206., PMID:9529385
• Effects of vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF) on haemodynamics and permselectivity of the isolated perfused rat kidney., PMID:9568844
• Proteolytic cleavage of versican and involvement of ADAMTS-1 in VEGF-A/VPF-induced pathological angiogenesis., PMID:21411713
• Isolation and purification of vascular endothelial growth factor (VEGF) from ascitic fluid of ovarian cancer patients., PMID:15188027

Specifications

Target	Vascular endothelial growth factor A
Reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
MW(Calculated)
MW(Observed)
Host Species	Humanized
Isotype	scFv-kappa-heavy
Conjugate/Modification
Modification
Recommended Dilution Ratio
Composition	0.01M PBS, pH 7.4.
Purification Process	Protein A/G purified from cell culture supernatant.
Purity	>95% purity as determined by SDS-PAGE.
Storage Condition	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Concentration
Clonality	Monoclonal
Clone Number
Immunogen	Mammalian Cells
Gene Name
Protein Name
Alias	Vascular endothelial growth factor A, VPF, VEGFA, VEGF, Vascular permeability factor, VEGF-A
Species
Gene ID-1	P15692
Uniprot
Species.1
Gene ID
Uniprot.1
Species.2
Gene ID.1
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Description	Background：Suvemcitug is a humanized IgG1κ antibody targeting VEGF derived from the African hare (Oryctolagus cuniculus).<br>• Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy., PMID:12409337<br />• Vascular endothelial growth factor and its receptors., PMID:7515293<br />• Tumors: wounds that do not heal-redux., PMID:25568067<br />• Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis., PMID:12461084<br />• Differential expression of vascular endothelial growth factor (vascular permeability factor) forms in rat tissues., PMID:8527159<br />• Hypoxia regulates the expression of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) and its receptors in human skin., PMID:9036922<br />• Synthesis, storage, and release of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) by human mast cells: implications for the biological significance of VEGF206., PMID:9529385<br />• Effects of vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF) on haemodynamics and permselectivity of the isolated perfused rat kidney., PMID:9568844<br />• Proteolytic cleavage of versican and involvement of ADAMTS-1 in VEGF-A/VPF-induced pathological angiogenesis., PMID:21411713<br />• Isolation and purification of vascular endothelial growth factor (VEGF) from ascitic fluid of ovarian cancer patients., PMID:15188027<br />
Cellular Localization
Tissue Expression
Signaling_pathway
Research Areas
Function