U-Blot® Research Grade Enokizumab
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$9,999.00
Product details
Background：Enokizumab (MEDI-528) is a monoclonal antibody targeting to interleukin (IL)-9. IL-9 regulates the development of airway inflammation, mucus production, airway hyperresponsiveness, and airway fibrosis largely by increasing mast cell numbers and activity in the airways.
• IL-9 secreted by leukemia stem cells induces Th1-skewed CD4+ T cells, which promote their expansion., PMID:38941612
• Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development., PMID:39164066
• The Role of Interleukin-9 in Cancer., PMID:31016637
• IL-9, a local growth factor for synovial T cells in inflammatory arthritis., PMID:26751012
• Locus of (IL-9) control: IL9 epigenetic regulation in cellular function and human disease., PMID:38825637
• Interleukin-9 and mast cells., PMID:23034251
• IL-9 sensitizes human TH2 cells to proinflammatory IL-18 signals in atopic dermatitis., PMID:39521283
• IL-9 and IL-9-producing cells in tumor immunity., PMID:32228589
• Interleukin-9 and T helper type 9 cells in rheumatic diseases., PMID:27159882
• IL-9-producing T cells: potential players in allergy and cancer., PMID:32788707
Specifications
| Target | |
| Reactivity | Human |
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Humanized |
| Isotype | IgG1-kappa |
| Conjugate/Modification | |
| Modification | |
| Recommended Dilution Ratio | |
| Composition | 0.01M PBS, pH 7.4. |
| Purification Process | Protein A/G purified from cell culture supernatant. |
| Purity | >95% as determined by SDS-PAGE. |
| Storage Condition | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | |
| Immunogen | Mammalian Cells |
| Gene Name | |
| Protein Name | |
| Alias | T-cell growth factor P40, Cytokine P40, IL9, Interleukin-9, IL-9 |
| Species | |
| Gene ID-1 | P15248 |
| Uniprot | |
| Species.1 | |
| Gene ID | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.1 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Description | Background：Enokizumab (MEDI-528) is a monoclonal antibody targeting to interleukin (IL)-9. IL-9 regulates the development of airway inflammation, mucus production, airway hyperresponsiveness, and airway fibrosis largely by increasing mast cell numbers and activity in the airways.<br>• IL-9 secreted by leukemia stem cells induces Th1-skewed CD4+ T cells, which promote their expansion., PMID:38941612<br />• Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development., PMID:39164066<br />• The Role of Interleukin-9 in Cancer., PMID:31016637<br />• IL-9, a local growth factor for synovial T cells in inflammatory arthritis., PMID:26751012<br />• Locus of (IL-9) control: IL9 epigenetic regulation in cellular function and human disease., PMID:38825637<br />• Interleukin-9 and mast cells., PMID:23034251<br />• IL-9 sensitizes human T<sub>H</sub>2 cells to proinflammatory IL-18 signals in atopic dermatitis., PMID:39521283<br />• IL-9 and IL-9-producing cells in tumor immunity., PMID:32228589<br />• Interleukin-9 and T helper type 9 cells in rheumatic diseases., PMID:27159882<br />• IL-9-producing T cells: potential players in allergy and cancer., PMID:32788707<br /> |
| Cellular Localization | |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function |
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