Name: U-Blot® Research Grade Inbakicept
SKU: WA2978
Price: 9999 USD
Availability: InStock

Product details

Background：Inbakicept is a dimeric human IL-15 receptor alpha (IL-15 Ra) sushi domain/human IgG1 Fc fusion protein and is an IL-15 superagonist complex. Inbakicept is able to form complex N-803 (Nogapendekin alfa inbakicept) with the IL-15 antibody Nogapendekin alfa in a 1:2 ratio. N-803 mimics the function of IL-15 and amplifies anti-CD20 mAb-mediated NK cell responses and antibody-dependent cellular cytotoxicity (ADCC). N-803 also increases degranulation and IFNγ production in cells.
• Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer., PMID:35660135
• Interleukin 15: A key cytokine for immunotherapy., PMID:27325459
• IL-15 in the Combination Immunotherapy of Cancer., PMID:32508818
• IL-27 enhances IL-15/IL-18-mediated activation of human natural killer cells., PMID:31277710
• Interleukin-15 in autoimmunity., PMID:32919253
• Interleukin-15-armoured GPC3 CAR T cells for patients with solid cancers., PMID:39604730
• An engineered concealed IL-15-R elicits tumor-specific CD8+T cell responses through PD-1-cis delivery., PMID:36165896
• IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease., PMID:32051586
• Engineering NK-CAR.19 cells with the IL-15/IL-15Rα complex improved proliferation and anti-tumor effect in vivo., PMID:37818365
• Systemic IL-15 promotes allogeneic cell rejection in patients treated with natural killer cell adoptive therapy., PMID:34797911

Specifications

Target	IL15
Reactivity	Human
Applications	ELISA, Functional assay, Research in vivo
MW(Calculated)
MW(Observed)
Host Species	Mammalian Cells
Isotype	Fusion - [IL15RA (interleukin 15 receptor subunit alpha, CD215, IL-15RA)]2 - IGHG1 Fc (Fragment constant)
Conjugate/Modification
Modification
Recommended Dilution Ratio
Composition	0.01M PBS, pH 7.4.
Purification Process	Protein A/G purified from cell culture supernatant.
Purity	>95% purity as determined by SDS-PAGE.
Storage Condition	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Concentration
Clonality
Clone Number
Immunogen	Mammalian Cells
Gene Name
Protein Name
Alias	IL15, IL-15, Interleukin-15
Species
Gene ID-1	P40933
Uniprot
Species.1
Gene ID
Uniprot.1
Species.2
Gene ID.1
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Description	Background：Inbakicept is a dimeric human IL-15 receptor alpha (IL-15 Ra) sushi domain/human IgG1 Fc fusion protein and is an IL-15 superagonist complex. Inbakicept is able to form complex N-803 (Nogapendekin alfa inbakicept) with the IL-15 antibody Nogapendekin alfa in a 1:2 ratio. N-803 mimics the function of IL-15 and amplifies anti-CD20 mAb-mediated NK cell responses and antibody-dependent cellular cytotoxicity (ADCC). N-803 also increases degranulation and IFNγ production in cells.<br>• Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer., PMID:35660135<br />• Interleukin 15: A key cytokine for immunotherapy., PMID:27325459<br />• IL-15 in the Combination Immunotherapy of Cancer., PMID:32508818<br />• IL-27 enhances IL-15/IL-18-mediated activation of human natural killer cells., PMID:31277710<br />• Interleukin-15 in autoimmunity., PMID:32919253<br />• Interleukin-15-armoured GPC3 CAR T cells for patients with solid cancers., PMID:39604730<br />• An engineered concealed IL-15-R elicits tumor-specific CD8+T cell responses through PD-1-cis delivery., PMID:36165896<br />• IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease., PMID:32051586<br />• Engineering NK-CAR.19 cells with the IL-15/IL-15Rα complex improved proliferation and anti-tumor effect <i>in vivo</i>., PMID:37818365<br />• Systemic IL-15 promotes allogeneic cell rejection in patients treated with natural killer cell adoptive therapy., PMID:34797911<br />
Cellular Localization
Tissue Expression
Signaling_pathway
Research Areas
Function