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Home/Reagents/Antibody/Biosimilar & Bispecific Antibodies/U-Blot® Research Grade Lirentelimab
SKU: WA3089 Categories: ,

U-Blot® Research Grade Lirentelimab

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$9,999.00

SKU: WA3089-50
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Product details

Background：Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis.
• Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen., PMID:23840825

Specifications

TargetSAF2
ReactivityHuman
ApplicationsELISA, Bioactivity: FACS, Functional assay, Research in vivo
MW(Calculated)
MW(Observed)
Host SpeciesHumanized
IsotypeIgG1-kappa
Conjugate/Modification
Modification
Recommended Dilution Ratio
Composition0.01M PBS, pH 7.4.
Purification ProcessProtein A/G purified from cell culture supernatant.
Purity>95% purity as determined by SDS-PAGE.
Storage ConditionUse a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Concentration
ClonalityMonoclonal
Clone Number
ImmunogenMammalian Cells
Gene Name
Protein Name
AliasSAF2, Sialoadhesin family member 2, SAF-2, Siglec-8, SIGLEC8, Sialic acid-binding Ig-like lectin 8
Species
Gene ID-1Q9NYZ4
Uniprot
Species.1
Gene ID
Uniprot.1
Species.2
Gene ID.1
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
DescriptionBackground：Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis.<br>• Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen., PMID:23840825<br />
Cellular Localization
Tissue Expression
Signaling_pathway
Research Areas
Function
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