Name: U-Blot® Research Grade Sifarobocept
SKU: WA3530
Price: 9999 USD
Availability: InStock

Product details

Background：Sifarobocept is a recombinant fusion protein comprising an roundabout guidance receptor 2 (ROBO2) fused to a human IgG1 Fc.
• Loss of Roundabout Guidance Receptor 2 (Robo2) in Podocytes Protects Adult Mice from Glomerular Injury by Maintaining Podocyte Foot Process Structure., PMID:32220420
• Conformational Change of the Hairpin-like-structured Robo2 Ectodomain Allows NELL1/2 Binding., PMID:35940226
• Robo2 contains a cryptic binding site for neural EGFL-like (NELL) protein 1/2., PMID:30700556
• Function of Slit/Robo signaling in breast cancer., PMID:26542734
• Genome-Wide Association Study Identifies ROBO2 as a Novel Susceptibility Gene for Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors., PMID:36508697
• Down-regulation of ROBO2 expression in prostate cancers., PMID:24272677
• Structural Principles in Robo Activation and Auto-inhibition., PMID:30853216
• ROBO2 hampers malignant biological behavior and predicts a better prognosis in pancreatic adenocarcinoma., PMID:34148491
• An ancient founder mutation located between ROBO1 and ROBO2 is responsible for increased microtia risk in Amerindigenous populations., PMID:35584116
• Alterations of ROBO1/DUTT1 and ROBO2 loci in early dysplastic lesions of head and neck: clinical and prognostic implications., PMID:19104841

Specifications

Target	Roundabout homolog 2
Reactivity	Human
Applications	ELISA, Functional assay, Research in vivo
MW(Calculated)
MW(Observed)
Host Species	Mammalian Cells
Isotype	Human ROBO2 fragment (1-203), fused to human IgG1 Fc fragment
Conjugate/Modification
Modification
Recommended Dilution Ratio
Composition	0.01M PBS, pH 7.4.
Purification Process	Protein A/G purified from cell culture supernatant.
Purity	>95% purity as determined by SDS-PAGE.
Storage Condition	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Concentration
Clonality
Clone Number
Immunogen	Mammalian Cells
Gene Name
Protein Name
Alias	Roundabout homolog 2, KIAA1568, ROBO2
Species
Gene ID-1	Q9HCK4
Uniprot
Species.1
Gene ID
Uniprot.1
Species.2
Gene ID.1
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Description	Background：Sifarobocept is a recombinant fusion protein comprising an roundabout guidance receptor 2 (ROBO2) fused to a human IgG1 Fc.<br>• Loss of Roundabout Guidance Receptor 2 (Robo2) in Podocytes Protects Adult Mice from Glomerular Injury by Maintaining Podocyte Foot Process Structure., PMID:32220420<br />• Conformational Change of the Hairpin-like-structured Robo2 Ectodomain Allows NELL1/2 Binding., PMID:35940226<br />• Robo2 contains a cryptic binding site for neural EGFL-like (NELL) protein 1/2., PMID:30700556<br />• Function of Slit/Robo signaling in breast cancer., PMID:26542734<br />• Genome-Wide Association Study Identifies <i>ROBO2</i> as a Novel Susceptibility Gene for Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors., PMID:36508697<br />• Down-regulation of ROBO2 expression in prostate cancers., PMID:24272677<br />• Structural Principles in Robo Activation and Auto-inhibition., PMID:30853216<br />• ROBO2 hampers malignant biological behavior and predicts a better prognosis in pancreatic adenocarcinoma., PMID:34148491<br />• An ancient founder mutation located between <i>ROBO1</i> and <i>ROBO2</i> is responsible for increased microtia risk in Amerindigenous populations., PMID:35584116<br />• Alterations of ROBO1/DUTT1 and ROBO2 loci in early dysplastic lesions of head and neck: clinical and prognostic implications., PMID:19104841<br />
Cellular Localization
Tissue Expression
Signaling_pathway
Research Areas
Function