Name: U-Blot® Research Grade Suvizumab
SKU: WA3587
Price: 9999 USD
Availability: InStock

U-Blot® Research Grade Suvizumab

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$9,999.00

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50ug

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SKU: WA3587-50

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Product details

Background：Suvizumab (KD-247) is an neutralizing antibody anti-HIV-1. Suvizumab effectively neutralizes HIV-1MN, HIV-1SF2 and HIV-189.6 with IC50 values of 0.1 µg/mL, 1.0 µg/mL and 0.2 µg/mL, respectively. Suvizumab reduces the viral load of HIV. Suvizumab has good tolerance and can be used to prevent HIV infection.
• Targeted infection of HIV-1 Env expressing cells by HIV(CD4/CXCR4) vectors reveals a potential new rationale for HIV-1 mediated down-modulation of CD4., PMID:16371160
• The intracytoplasmic domain of the Env transmembrane protein is a locus for attenuation of simian immunodeficiency virus SIVmac in rhesus macaques., PMID:10846063
• Differences in feline immunodeficiency virus host cell range correlate with envelope fusogenic properties., PMID:7856093
• Incomplete protection, but suppression of virus burden, elicited by subunit simian immunodeficiency virus vaccines., PMID:8107246
• Mechanistic analysis of pause site-dependent and -independent recombinogenic strand transfer from structurally diverse regions of the HIV genome., PMID:15342633

Specifications

Target	env/Env polyprotein
Reactivity	Human immunodeficiency virus 1 (HIV-1)
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
MW(Calculated)
MW(Observed)
Host Species	Humanized
Isotype	IgG1, kappa
Conjugate/Modification
Modification
Recommended Dilution Ratio
Composition	0.01M PBS, pH 7.4.
Purification Process	Protein A/G purified from cell culture supernatant.
Purity	>95% purity as determined by SDS-PAGE.
Storage Condition	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Concentration
Clonality	Monoclonal
Clone Number
Immunogen	Mammalian Cells
Gene Name
Protein Name
Alias	env/Env polyprotein
Species
Gene ID-1	P03377
Uniprot
Species.1
Gene ID
Uniprot.1
Species.2
Gene ID.1
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Description	Background：Suvizumab (KD-247) is an neutralizing antibody anti-HIV-1. Suvizumab effectively neutralizes HIV-1MN, HIV-1SF2 and HIV-189.6 with IC50 values of 0.1 µg/mL, 1.0 µg/mL and 0.2 µg/mL, respectively. Suvizumab reduces the viral load of HIV. Suvizumab has good tolerance and can be used to prevent HIV infection.<br>• Targeted infection of HIV-1 Env expressing cells by HIV(CD4/CXCR4) vectors reveals a potential new rationale for HIV-1 mediated down-modulation of CD4., PMID:16371160<br />• The intracytoplasmic domain of the Env transmembrane protein is a locus for attenuation of simian immunodeficiency virus SIVmac in rhesus macaques., PMID:10846063<br />• Differences in feline immunodeficiency virus host cell range correlate with envelope fusogenic properties., PMID:7856093<br />• Incomplete protection, but suppression of virus burden, elicited by subunit simian immunodeficiency virus vaccines., PMID:8107246<br />• Mechanistic analysis of pause site-dependent and -independent recombinogenic strand transfer from structurally diverse regions of the HIV genome., PMID:15342633<br />
Cellular Localization
Tissue Expression
Signaling_pathway
Research Areas
Function