U-Blot® Research Grade Toripalimab

$9,999.00

SKU: WA3686-50
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Product details

Background:Balstilimab is a novel, fully human monoclonal immunoglobulin G4 (IgG4) designed to block PD-1 (programmed cell death protein 1) from interacting with its ligands PD-L1 and PD-L2. PD-1 is a negative regulator of immune activation that is considered a foundational target within the immuno-oncology market.
• The blockade of immune checkpoints in cancer immunotherapy., PMID:22437870
• PD-1 and PD-L1 in cancer immunotherapy: clinical implications and future considerations., PMID:30888929
• The diverse functions of the PD1 inhibitory pathway., PMID:28990585
• PD-1/PD-L1 immune checkpoint: Potential target for cancer therapy., PMID:30191996
• Immune Checkpoint Blockade in Cancer Therapy., PMID:25605845
• PD-1 expression and clinical PD-1 blockade in B-cell lymphomas., PMID:29118007
• Overcoming T cell exhaustion in infection and cancer., PMID:25797516
• Study and analysis of antitumor resistance mechanism of PD1/PD-L1 immune checkpoint blocker., PMID:32875727
• Tumor Mutational Burden and Response Rate to PD-1 Inhibition., PMID:29262275
• PD-L1., PMID:29097600

Specifications

TargetCD1
ReactivityHuman
ApplicationsELISA, Bioactivity: FACS, Functional assay, Research in vivo
MW(Calculated)
MW(Observed)
Host SpeciesHumanized
IsotypeIgG4-kappa
Conjugate/Modification
Modification
Recommended Dilution Ratio
Composition0.01M PBS, pH 7.4.
Purification ProcessProtein A/G purified from cell culture supernatant.
Purity>95% purity as determined by SDS-PAGE.
Storage ConditionUse a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Concentration
ClonalityMonoclonal
Clone Number
ImmunogenMammalian Cells
Gene Name
Protein Name
AliasProgrammed cell death protein 1, Protein PD-1, hPD-1, PD1, PDCD1, CD279
Species
Gene ID-1Q15116
Uniprot
Species.1
Gene ID
Uniprot.1
Species.2
Gene ID.1
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
DescriptionBackground:Balstilimab is a novel, fully human monoclonal immunoglobulin G4 (IgG4) designed to block PD-1 (programmed cell death protein 1) from interacting with its ligands PD-L1 and PD-L2. PD-1 is a negative regulator of immune activation that is considered a foundational target within the immuno-oncology market.<br>• The blockade of immune checkpoints in cancer immunotherapy., PMID:22437870<br />• PD-1 and PD-L1 in cancer immunotherapy: clinical implications and future considerations., PMID:30888929<br />• The diverse functions of the PD1 inhibitory pathway., PMID:28990585<br />• PD-1/PD-L1 immune checkpoint: Potential target for cancer therapy., PMID:30191996<br />• Immune Checkpoint Blockade in Cancer Therapy., PMID:25605845<br />• PD-1 expression and clinical PD-1 blockade in B-cell lymphomas., PMID:29118007<br />• Overcoming T cell exhaustion in infection and cancer., PMID:25797516<br />• Study and analysis of antitumor resistance mechanism of PD1/PD-L1 immune checkpoint blocker., PMID:32875727<br />• Tumor Mutational Burden and Response Rate to PD-1 Inhibition., PMID:29262275<br />• PD-L1., PMID:29097600<br />
Cellular Localization
Tissue Expression
Signaling_pathway
Research Areas
Function
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