Name: U-Blot® RHEB Rabbit mAb
SKU: WR5439
Price: 268 USD
Availability: InStock

U-Blot® RHEB Rabbit mAb

Ucallm_WR5439-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WR5439-50

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Product details

Background:This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	RHEB
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)	21kD
MW(Observed)	21kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1285R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	RHEB RHEB2
Protein Name	RHEB
Other Name	Ras homolog enriched in brain
Species	Human
Gene ID	6009
Uniprot	Q15382,
Species.1	Mouse
Gene ID.1	19744
Uniprot.1	Q921J2,
Species.2	Rat
Gene ID.2
Uniprot.2	Q62639
Cellular Localization	Endomembrane system; Lipid-anchor; Cytoplasmic side . Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side . Cytoplasm, cytosol . Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side .
Tissue Expression	Ubiquitous. Highest levels observed in skeletal and cardiac muscle.
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Autophagy - animal;Cellular Processes >> Cell growth and death >> Cellular senescence;Organismal Systems >> Endocrine system >> Insulin signaling pathway;Organismal Systems >> Endocrine system >> Thyroid hormone signaling pathway;Organismal Systems >> Aging >> Longevity regulating pathway;Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Environmental Information Processing >> Signal transduction >> AMPK signaling pathway;Environmental Information Processing >> Signal transduction >> mTOR signaling pathway
Research Areas	>>Phospholipase D signaling pathway; / >>Autophagy - animal; / >>mTOR signaling pathway; / >>PI3K-Akt signaling pathway; / >>AMPK signaling pathway; / >>Longevity regulating pathway; / >>Cellular senescence; / >>Thermogenesis; / >>Insulin signaling pathway; / >>Thyroid hormone signaling pathway; / >>Human cytomegalovirus infection; / >>Human papillomavirus infection; / >>Herpes simplex virus 1 infection; / >>Choline metabolism in cancer
Function	Function:Not known; binds GTP and exhibits intrinsic GTPase activity.,similarity:Belongs to the small GTPase superfamily. Rheb family.,tissue specificity:Ubiquitous. Highest levels observed in skeletal and cardiac muscle.,