SKU: WR5078 Categories: ,

U-Blot® SFRS3 Rabbit mAb

Price range: $268.00 through $328.00

SKU: WR5078-100
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Product details

Background:The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. [provided by RefSeq, Sep 2010],

Specifications

Size50μL/100μL
TargetSRp20
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)19kD
MW(Observed)22kD
Host SpeciesRabbit
IsotypeIgG,Kappa
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
PurificationRecombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone NumberRM1319R
ImmunogenThe specific immunogen used to produce this antibody is proprietary information.
SpecificityEndogenous
Gene NameSRSF3
Protein NameSerine/arginine-rich splicing factor 3
Other NameSRSF3; / SFRS3; / SRP20; / Serine/arginine-rich splicing factor 3; / Pre-mRNA-splicing factor SRP20; / Splicing factor; / arginine/serine-rich 3
SpeciesHuman
Gene ID6428
UniprotP84103,
Species.1Mouse
Gene ID.120383
Uniprot.1P84104
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationNucleus . Nucleus speckle . Cytoplasm . Recruited to nuclear speckles following interaction with YTHDC1. .
Tissue ExpressionBrain,Epithelium,Placenta,Tongue,
Signaling_pathwayHuman Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis
Research Areas>>Spliceosome; / >>Amyotrophic lateral sclerosis; / >>Herpes simplex virus 1 infection
FunctionFunction:May be involved in RNA processing in relation with cellular proliferation and/or maturation.,PTM:Extensively phosphorylated on serine residues in the RS domain.,similarity:Belongs to the splicing factor SR family.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Interacts with CPSF6, RBMY1A1 and SFRS12.,
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