Price range: $268.00 through $328.00
Background:The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010],
| Size | 50μL/100μL |
| Target | Smo |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF, IP, ELISA |
| MW(Calculated) | 86kD |
| MW(Observed) | 100kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1379R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | SMO |
| Protein Name | Smoothened homolog |
| Other Name | SMO; / SMOH; / Smoothened homolog; / SMO; / Protein Gx |
| Species | Human |
| Gene ID | 6608 |
| Uniprot | Q99835, |
| Species.1 | Mouse |
| Gene ID.1 | 319757 |
| Uniprot.1 | P56726, |
| Species.2 | Rat |
| Gene ID.2 | 25273 |
| Uniprot.2 | P97698 |
| Cellular Localization | Membrane; Multi-pass membrane protein . Cell projection, cilium . |
| Tissue Expression | Brain,Embryonic lung,Synovial membrane, |
| Signaling_pathway | Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Basal cell carcinoma;Environmental Information Processing >> Signal transduction >> Hedgehog signaling pathway |
| Research Areas | >>Hedgehog signaling pathway; / >>Axon guidance; / >>Pathways in cancer; / >>Proteoglycans in cancer; / >>Basal cell carcinoma |
| Function | Disease:Defects in SMO are involved in basal cell carcinoma (BCC).,Function:G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO).,similarity:Belongs to the G-protein coupled receptor Fz/Smo family.,similarity:Contains 1 FZ (frizzled) domain., |
