Price range: $268.00 through $328.00
Background：
This gene encodes a member of the beta tubulin family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene cause hypomyelinating leukodystrophy-6 and autosomal dominant torsion dystonia-4. Alternate splicing results in multiple transcript variants encoding different isoforms. A pseudogene of this gene is found on chromosome X. [provided by RefSeq , Jan 2014] ,
| Size | 50μL/100μL |
| Target | TBB4A |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 50kD |
| MW(Observed) | 50kD |
| Host Species | Rabbit |
| Isotype | IgG, Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year (Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1950R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | TUBB4A TUBB4 TUBB5 |
| Protein Name | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) |
| Other Name | |
| Species | Human |
| Gene ID | 10382 |
| Uniprot | P04350, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9D6F9 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm , cytoskeleton. |
| Tissue Expression | Major isotype in brain , where it represents 46% of all beta-tubulins. In the brain , highest expression levels in the cerebellum , followed by putamen and white matter. Moderate levels in testis. Very low levels , if any , in other tissues. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome;Cellular Processes >> Cellular community - eukaryotes >> Gap junction;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Parkinson disease;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Huntington disease;Human Diseases >> Neurodegenerative disease >> Prion disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases |
| Research Areas | >>Phagosome; / >>Gap junction; / >>Alzheimer disease; / >>Parkinson disease; / >>Amyotrophic lateral sclerosis; / >>Huntington disease; / >>Prion disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Pathogenic Escherichia coli infection; / >>Salmonella infection |
| Function | Domain:The highly acidic C-terminal region may bind cations such as calcium. ,Function:Tubulin is the major constituent of microtubules. It binds two moles of GTP , one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. ,similarity:Belongs to the tubulin family. ,subunit:Dimer of alpha and beta chains. , |
