Name: U-Blot® TCL1 Mouse mAb (Ready to Use)
SKU: WM1745R
Price: 168 USD
Availability: InStock

U-Blot® TCL1 Mouse mAb (Ready to Use)

Ucallm_WM1745R

$168.00

Product details

Background：
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010],

Specifications

Target	TCL1
Reactivity	Human
Applications	IHC
MW(Calculated)
MW(Observed)
Host Species	Mouse
Isotype	IgG2b,Kappa
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	Ready to use for IHC / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation	The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
Source
Purification	The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Purity
Storage	2°C to 8°C/1 year,Ship by ice bag
Concentration
Clonality	Monoclonal
Clone Number	ABT378
Immunogen	Synthesized peptide derived from human TCL1 AA range: 50-114
Sequence
Specificity	The antibody can specifically recognize human TCL1 protein.
Gene Name	TCL1A TCL1
Protein Name	TCL1
Other Name	T-cell leukemia/lymphoma protein 1A; / Oncogene TCL-1; / Oncogene TCL1; / Protein p14 TCL1
Species	Human
Gene ID-1	8115
Uniprot	P56279
Species.1
Gene ID-2
Uniprot.1
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010],
Cellular Localization	Cytoplasmic, Nuclear
Tissue Expression	Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.
Signaling_pathway	Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Research Areas	>>PI3K-Akt signaling pathway
Function	Disease:Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14; 14)(q11; q32); translocation t(7; 14)(q35; q32); inversion inv(14)(q11; q32) that involves the T-cell receptor alpha/delta locuses.,Function:Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.,similarity:Belongs to the TCL1 family.,subcellular location:Microsomal fraction.,subunit:Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity.,tissue specificity:Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.,
RRID