U-Blot® TCL1 Rabbit mAb (Ready to Use)
Ucallm_WR8107
$168.00
Product details
Background：
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010],
Specifications
| Size | 6mL |
| Target | TCL1 |
| Reactivity | Human |
| Applications | IHC |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG1,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | Ready to use for IHC / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300 |
| Purification | Recombinant Expression and Affinity purified |
| Storage | 2°C to 8°C/1 year,Ship by ice bag |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM0225R |
| Immunogen | Synthesized peptide derived from human TCL1 AA range:50-114 |
| Specificity | This antibody detects endogenous levels of TCL1 |
| Gene Name | TCL1A |
| Protein Name | TCL1 |
| Other Name | Anti TCL1A; / Lymphoma/leukemia, T-cell; / Oncogene TCL-1; / Oncogene TCL1; / P14 TCL1; / P14 TCL1 protein; / Protein p14 TCL1; / T cell leukemia 1; / T cell lymphoma 1; / T cell lymphoma 1A; / T-cell leukemia/lymphoma 1A; / T-cell leukemia/lymphoma protein 1A; / TCL 1 protein; / TCL1; / TCL1 oncogene; / TCL1 PEN; / Tcl1a; / TCL1A; / TCL1A_HUMAN |
| Species | Human |
| Gene ID | 8115 |
| Uniprot | P56279 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasmic, Nuclear |
| Tissue Expression | Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway |
| Research Areas | >>PI3K-Akt signaling pathway |
| Function | Disease:Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14; 14)(q11; q32); translocation t(7; 14)(q35; q32); inversion inv(14)(q11; q32) that involves the T-cell receptor alpha/delta locuses.,Function:Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.,similarity:Belongs to the TCL1 family.,subcellular location:Microsomal fraction.,subunit:Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity.,tissue specificity:Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation., |
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