U-Blot® TIA1 Rabbit mAb
Ucallm_WR5953-50
Price range: $268.00 through $328.00
Product details
Background：
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly (A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. [provided by RefSeq , Jul 2008] ,
Specifications
| Size | 50μL/100μL |
| Target | TIA1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | 43kD |
| MW(Observed) | 42,44kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1891R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | TIA1 |
| Protein Name | Nucleolysin TIA-1 isoform p40 (RNA-binding protein TIA-1) (T-cell-restricted intracellular antigen-1) (TIA-1) (p40-TIA-1) |
| Other Name | |
| Species | Human |
| Gene ID | 7072 |
| Uniprot | P31483, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P52912 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Cytoplasm . Cytoplasm, Stress granule . Accumulates in cytoplasmic stress granules (SG) following cellular damage (PubMed:15371533, PubMed:10613902). Recruitment to SG is induced by Zn(2+) (By similarity). . |
| Tissue Expression | Expressed in heart, small intestine, kidney, liver, lung, skeletal muscle, testes, pancreas, and ovary (at protein level). |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.,PTM:TIA-1 major granule-associated species is a 15-kDa protein (p15-TIA-1) that seems to be derived by proteolytic processing from the C-terminus of p40-TIA-1.,similarity:Contains 3 RRM (RNA recognition motif) domains.,subcellular location:Cytoplasmic granules of cytolytic T-lymphocytes., |
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