U-Blot® TMEM173 Rabbit mAb
Ucallm_WR6094-50
Price range: $268.00 through $328.00
Product details
Background:This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq , Sep 2014] ,
Specifications
| Size | 50μL/100μL |
| Target | STING/TMEM173 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | 42kD |
| MW(Observed) | 36kD |
| Host Species | Rabbit |
| Isotype | IgG, Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year (Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM2161R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | TMEM173 ERIS MITA STING |
| Protein Name | Transmembrane protein 173 |
| Other Name | TMEM173; / ERIS; / MITA; / STING; / Transmembrane protein 173; / Endoplasmic reticulum interferon stimulator; / ERIS; / Mediator of IRF3 activation; / hMITA; / Stimulator of interferon genes protein; / hSTING |
| Species | Human |
| Gene ID | 340061 |
| Uniprot | Q86WV6 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasmic , Membranous |
| Tissue Expression | Ubiquitously expressed. Expressed in skin endothelial cells , alveolar type 2 pneumocytes , bronchial epithelium and alveolar macrophages. |
| Signaling_pathway | Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Organismal Systems >> Immune system >> RIG-I-like receptor signaling pathway;Organismal Systems >> Immune system >> Cytosolic DNA-sensing pathway |
| Research Areas | >>NOD-like receptor signaling pathway; / >>RIG-I-like receptor signaling pathway; / >>Cytosolic DNA-sensing pathway; / >>Shigellosis; / >>Human cytomegalovirus infection; / >>Herpes simplex virus 1 infection; / >>Human immunodeficiency virus 1 infection; / >>Coronavirus disease - COVID-19 |
| Function | Function:Acts as a facilitator of innate immune signaling. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. May be involved in translocon function , the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) . Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. ,PTM:Phosphorylated on tyrosine residues upon MHC-II aggregation. ,subunit:Associates with the MHC-II complex (By similarity) . Interacts with DDX58/RIG-I , MAVS/VISA and SSR2. ,tissue specificity:Ubiquitously expressed. , |
Please login to post questions
Related products
