Name: U-Blot® TPO Rabbit mAb
SKU: WR5376
Price: 268 USD
Availability: InStock

U-Blot® TPO Rabbit mAb

Ucallm_WR5376-50

Price range: $268.00 through $328.00

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50μl

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SKU: WR5376-50

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Product details

Background:Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014],

Specifications

Size	50μL/100μL
Target	TPO
Reactivity	Human
Applications	WB, IHC, IF, ELISA
MW(Calculated)	38kD
MW(Observed)	38kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1620R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	THPO
Protein Name	Thrombopoietin
Other Name	THPO; / MGDF; / Thrombopoietin; / C-mpl ligand; / ML; / Megakaryocyte colony-stimulating factor; / Megakaryocyte growth and development factor; / MGDF; / Myeloproliferative leukemia virus oncogene ligand
Species	Human
Gene ID	7066
Uniprot	P40225,
Species.1	Mouse
Gene ID.1	21832
Uniprot.1	P40226,
Species.2	Rat
Gene ID.2	81811
Uniprot.2	P49745
Cellular Localization	Secreted.
Tissue Expression	Brain,Fetal liver,Liver,Placenta,
Signaling_pathway	Organismal Systems >> Immune system >> Hematopoietic cell lineage;Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Research Areas	>>Cytokine-cytokine receptor interaction; / >>JAK-STAT signaling pathway; / >>Hematopoietic cell lineage
Function	Disease:Defects in THPO are a cause of essential thrombocythemia (ET) [MIM:187950]. ET is inherited as an autosomal dominant trait which is characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications.,Domain:Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal.,Function:Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.,similarity:Belongs to the EPO/TPO family.,

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U-Blot® TPO Rabbit mAb

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U-Blot® TPO Rabbit mAb

Product details

Specifications

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