Name: U-Blot® TRPV4 Rabbit mAb
SKU: WR5400
Price: 268 USD
Availability: InStock

Product details

Background:transient receptor potential cation channel subfamily V member 4(TRPV4) Homo sapiens This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010],

Specifications

Size	50μL/100μL
Target	TRPV4
Reactivity	Human
Applications	WB, IF, IP, ELISA
MW(Calculated)	98kD
MW(Observed)	90-100kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:1000-1:5000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200;
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1647R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	TRPV4
Protein Name	Transient receptor potential cation channel subfamily V member 4
Other Name	TRPV4; / VRL2; / VROAC; / Transient receptor potential cation channel subfamily V member 4; / TrpV4; / Osm-9-like TRP channel 4; / OTRPC4; / Transient receptor potential protein 12; / TRP12; / Vanilloid receptor-like channel 2; / Vanilloid receptor-like protein 2; / VRL-2; / Vanilloid receptor-related osmotically-activated channel; / VR-OAC
Species	Human
Gene ID	59341
Uniprot	Q9HBA0,
Species.1	Mouse
Gene ID.1	63873
Uniprot.1	Q9EPK8,
Species.2	Rat
Gene ID.2	66026
Uniprot.2	Q9ERZ8
Cellular Localization	Cell membrane . Apical cell membrane; Multi-pass membrane protein . Cell junction, adherens junction . Cell projection, cilium . Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum. .; [Isoform 1]: Cell membrane .; [Isoform 5]: Cell membrane .; [Isoform 2]: Endoplasmic reticulum .; [Isoform 4]: Endoplasmic reticulum .; [Isoform 6]: Endoplasmic reticulum .
Tissue Expression	Found in the synoviocytes from patients with (RA) and without (CTR) rheumatoid arthritis (at protein level).
Signaling_pathway	Cellular Processes >> Cell growth and death >> Cellular senescence;Organismal Systems >> Sensory system >> Inflammatory mediator regulation of TRP channels
Research Areas	>>Cellular senescence; / >>Inflammatory mediator regulation of TRP channels; / >>Fluid shear stress and atherosclerosis
Function	Disease:Defects in TRPV4 are the cause of brachyolmia type 3 [MIM:113500]; also called brachyrachia. The brachyolmias constitute a clinically and genetically heterogeneous group of skeletal dysplasias characterized by a short trunk, scoliosis and mild short stature. Type 3 brachyolmia is an autosomal dominant form with severe kyphoscoliosis and flattened, irregular cervical vertebrae.,Function:Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism.,similarity:Belongs to the transient receptor family. TrpV subfamily.,similarity:Contains 3 ANK repeats.,subcellular location:Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum.,subunit:Homotetramer (Probable). Self-associates in a isoform-specific manner. Isoforms 1/A and 5/D but not isoform 2/B, 4/C and 6/E can oligomerize. Interacts with calmodulin. Interacts with Map7 and Src family Tyr protein kinases LYN, SRC, FYN, HCK, LCK and YES.,